Baltimore visits Indianapolis as a 3.5-point road favorite, but this Ravens vs. Colts preview isn’t simply about which quarterback has the bigger name. Our projections point to two different offensive paths: the Ravens leaning on their ground game and the Colts asking their passing attack to carry more of the workload.
That contrast makes the spread interesting without making it automatic. Baltimore brings the stronger recent outright record and the more productive rushing projection. Indianapolis has home field and closed last season with better results against the spread than its win-loss record might suggest.
Ravens vs. Colts game details and latest odds
- Matchup: Baltimore Ravens at Indianapolis Colts
- Kickoff: Sunday, September 13 at 1 p.m. EDT
- Venue: Lucas Oil Stadium in Indianapolis
- Spread: Ravens -3.5 (-105); Colts +3.5 (-115)
- Total: 47.5, with over -115 and under -105
The latest spread and total come from DraftKings. The game also opens a new chapter for two teams coming off 8-9 seasons in 2025. NBC Sports notes that Jesse Minter is making his debut as Baltimore’s head coach, adding another variable to an already unpredictable Week 1 matchup.
Two offenses with different routes to production
With Lamar Jackson at quarterback and Derrick Henry leading the backfield, Baltimore has a clear foundation for its rushing attack. Our projections put the Ravens at roughly 155 rushing yards on about 31 attempts, compared with around 103 yards on 25 carries for Indianapolis.
The passing-volume outlook flips that picture. Indianapolis projects for about 33 attempts and 215 passing yards with Daniel Jones listed as its starting quarterback. Baltimore comes in closer to 25 attempts and 175 passing yards. The Colts may need to sustain drives through a higher-volume passing game, while the Ravens have more room to build their offense on the ground.
The overall yardage estimates are still fairly close: approximately 330 for Baltimore and 318 for Indianapolis. That makes game shape especially important. The Ravens would rather let their rushing attack set the terms, while the Colts need their additional passing volume to translate into efficient, sustained offense.
Last season offers a useful spread reminder
Across each team’s final 10 games of the 2025 season, Baltimore went 6-4 overall and Indianapolis finished 2-8. Against the spread, however, the gap disappeared: the Ravens were 4-6 ATS and the Colts were 5-5.
That’s worth remembering with the line sitting at 3.5 points. Baltimore’s stronger outright finish helps explain why it’s favored, but picking the more likely winner and finding value against the spread are two different decisions.
Fresh Baltimore absences to monitor
The current injury report has Baltimore defensive tackle Nnamdi Madubuike out with a neck injury and linebacker Teddye Buchanan out with an ACL injury. Wide receiver Devontez Walker is questionable with a groin issue. Indianapolis linebacker Austin Ajiake is questionable because of a hamstring injury.
Madubuike and Buchanan leave Baltimore with two confirmed absences in its defensive front seven. Walker’s status is the main listed uncertainty on the Ravens’ offense, while Ajiake is the Colts’ only fresh injury designation supplied for this matchup.
Sharpest Bets Premium
See the picks behind the stars.
Explore our model’s selections, projections and matchup analysis. Start with a free 7-day trial, then save 20% every month with code PREVIEW20.
How the spread and total compare
Our ratings show a three-star total and one-star side. The spread remains the main market for this NFL matchup, but that gap in strength makes the 47.5 total the more notable secondary question.
For the spread, Baltimore’s projected rushing advantage is the clearest argument supporting its status as the road favorite. Indianapolis can counter by turning its expected passing volume into sustained drives and keeping the game within one possession. With Week 1 uncertainty, a new Baltimore coaching staff and modest side strength, the price deserves more attention than the team names alone.
See the latest lines, player markets, ratings and full matchup details on the Baltimore Ravens vs. Indianapolis Colts matchup.
Odds and projections are snapshots and can change. Wagering involves risk.